U-M receives $3.1M to transform post-stroke mobility treatment


A close look at how the ankle functions after a stroke could ultimately improve the mobility and rehabilitation outcomes for more than 40 million stroke survivors worldwide who experience persistent walking difficulties.

Supported by a $3.1 million grant from the National Institutes of Health, University of Michigan researchers will focus on how stroke affects the two fundamental properties of the ankle joint during human walking — and how a common medication may, or may not, help.

“Joint stiffness is a key factor in energy storage and forward movement, while joint viscosity describes resistance during gait,” said Elliott Rouse, associate professor of robotics and of mechanical engineering in the College of Engineering, and co-principal investigator of the project. “Unfortunately, these essential parameters are currently unaccounted for or misjudged in clinical settings.”

In addition to quantifying how these two properties affect how well people walk after experiencing a stroke, the team will develop a tool so medical practitioners can easily measure them as well.

“Through this research, and by establishing a new tool to measure ankle properties in the clinic, we can advance our understanding, improve treatments and ultimately empower stroke survivors to regain mobility. This could enhance overall quality of life for millions of stroke survivors,” Rouse said.

Contrary to previous beliefs that ankle joint stiffness and viscosity both increase following a stroke, recent studies have revealed that these parameters remain unchanged or can even decrease compared to the unaffected side of the body. This misconception shows the need to investigate and understand the mechanics involved in order to develop more effective treatments.

One treatment in use now is botulinum neurotoxin injections, which are used to reduce joint stiffness. The team will study how they affect the properties of the ankle — and the implications for mobility.

“Studying these mechanics is especially crucial because BoNT injections may further reduce ankle joint stiffness and viscosity, potentially hindering mobility,” said Chandramouli Krishnan, associate professor of physical medicine and rehabilitation, and of biomedical engineering in the Medical School, associate professor of physical therapy at UM-Flint, and co-principal investigator.

“Our grant will not only investigate how ankle properties change after a stroke, but also assess the effects of BoNT injections and determine their impact on patient outcomes,” he said.

The research team includes Edward Claflin, assistant professor of physical medicine and rehabilitation; James Richardson, professor of physical medicine and rehabilitation; and Corey Powell, a statistician expert and adjunct professor of statistics in LSA.

“Our team is uniquely qualified to perform this research, as we have experts in biomedical and mechanical engineering, robotics, stroke rehabilitation, gait biomechanics and modeling, and clinician scientists, in addition to a world-class rehabilitation hospital,” Krishnan said.


Leave a comment

Commenting is closed for this article. Please read our comment guidelines for more information.