Study looks at long-term severe substance use disorder


While it’s estimated that 1 in 3 Americans will develop a substance use disorder in their lifetime, experts know little about the long-term outcomes for people with substance use disorder symptoms from adolescence through adulthood.

New University of Michigan research findings on the topic are grim: The majority of 18-year-olds with severe substance use disorder symptoms who were followed in a longitudinal study over 32 years still had multiple substance use disorder symptoms as adults.


The study from the School of Nursing, appearing in JAMA Network Open, found:

  • An estimated 12% of 18-year-olds had severe substance use disorder, or SUD, symptoms.
  • U.S. adolescents with severe SUD symptoms were significantly more likely to report prescription drug misuse in adulthood.
  • The relationship between severe SUD symptoms and later SUD symptoms also held for adolescents with severe alcohol, cannabis and other drug use disorder symptoms.
  • Most adults in the study prescribed opioids, benzodiazepines or other sedatives/tranquilizers had multiple SUD symptoms during adolescence.

“This is a major wake-up call,” said lead author Sean Esteban McCabe, professor of nursing and director of the Center for the Study of Drugs, Alcohol, Smoking, and Health. “The majority of middle-aged adults being prescribed these medications had multiple substance use disorder symptoms at age 18, raising serious concerns about the safety of prescribing controlled substances to these individuals. 

“Some of the disorders and conditions we treat with these same medications are also associated with an increased risk for substance use disorder, such as anxiety disorders, sleep disorders and pain.

“We must rethink how we screen and prescribe to individuals who have multiple substance use disorder symptoms in their past, because they might need additional help to take their medication safely. For example, some people in long-term recovery from substance use disorders use ‘gatekeepers’ to help dispense and dispose of medications, and lockboxes to reduce access to only the gatekeepers.”

Most of the people in the study did not seek treatment, and the findings suggest the need to find ways of offering treatment over long periods of time even if the person isn’t ready for help, McCabe said. Better screening, prevention and education through adulthood would also help.

“Screening that accounts for polysubstance use and substance use disorder symptom severity during adolescence can identify individuals at the greatest risk for prescription drug misuse and substance use disorder in adulthood,” McCabe said.

Additionally, insurers can assist by helping cover the time it takes for wraparound services, and counties and states can use the opioid settlement funds to invest in evidence-based prevention and treatment efforts, he said.

McCabe and colleagues sought to understand the association between an adolescent’s substance use disorder symptom severity and later medical use of prescription drugs, prescription drug misuse and substance use disorder symptoms at ages 35-50.

Eleven cohorts of 12th-graders were followed from age 18 to age 50 in the Monitoring the Future study, one of the nation’s most relied upon sources of information on emerging trends in illicit drug, alcohol and tobacco use among American adolescents, college students and young and middle-aged adults. 

Subsequent studies will examine the role of stimulant and nonstimulant medication to treat ADHD and the later misuse of stimulants and other drugs. The current study is funded by the National Institute on Drug Abuse, part of the National Institutes of Health.

Co-authors include John Schulenberg, Philip Veliz and Vita McCabe of U-M, and Ty Schepis of Texas State University. All are members of U-M’s Center for the Study of Drugs, Alcohol, Smoking, and Health.



  1. Amanda Louks
    on April 4, 2022 at 1:38 pm

    Families dealing with this issue know full well the support that is needed and is not available. This report is right on with real world experience. Substance abuse is tied to mental health, inextricably. When seeking help often times one must choose substance abuse help or mental health help and in my experience as a family member, you cannot separate the two. They go hand in hand. Forcing one of the other upon the person doesn’t work and doesn’t help. It may even make it worse. The lack of long term support and guard rails for those tough cases is real. These people fall through the cracks and they don’t survive and they suffer greatly. I appreciate these studies. I wonder when the results will affect policy and available resources. It is desperately needed.

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