A U-M Health System laboratory study reveals a key trigger for producing normal red blood cells that could lead to a new treatment for those with sickle cell disease.
The study, conducted in mice, appears in last week’s early edition of the Proceedings of the National Academy of Sciences, and holds promise for preventing the painful episodes and organ damage that are common complications of sickle cell disease.
According to the U-M study, increasing the expression of the proteins, TR2 and TR4, more than doubled the level of fetal hemoglobin produced in sickle cell mice and reduced organ damage.
“The vast majority of sickle cell disease patients are diagnosed early in childhood when adult hemoglobin normally replaces fetal hemoglobin, but the severity of the disease can differ markedly, correlating most strongly with the level of fetal hemoglobin present in red cells,” says pediatrician and lead study author Dr. Andrew D. Campbell, director of the Pediatric Comprehensive Sickle Cell Program at the Comprehensive Cancer Center.
Sickle cell is an inherited blood disorder impacting millions of patients worldwide that causes normal red blood cells to change shape to a crescent moon.
The result is debilitating pain episodes, chronic organ damage and a significantly shortened life span.
Sickle cell disease occurs in 1 out of every 500 African-American births and 1 out of every 36,000 Hispanic-American births, according to the Sickle Cell Disease Association of America, Inc.
It’s most common among those with an ancestry to Africa, South and Central America, the Caribbean islands, India, Saudi Arabia and Mediterranean countries such as Turkey, Greece and Italy.
The study team, that included experts in hematology oncology, cell and developmental biology and pathology from the U-M and the University of Tsukuba, Japan, demonstrated a potential method for boosting the fetal hemoglobin levels by modulating TR2/TR4 expression.
“While the average fetal hemoglobin was 7.6 percent in the sickle cell mice, the TR2/TR4 treated sickle cell mice had an average fetal hemoglobin of 18.6 percent,” says senior study author James Douglas Engel, professor and chair of the U-M’s Cell and Development Biology Department.
It’s the first time specific proteins have been targeted to prevent a disease, he says.
Additional U-M authors include Shuaiying Cui, Lihong Shi, Rebekah Urbonya, Andrea Mathias, Kori Bradley, Kwaku O. Bonsua, Rhonda R. Douglas, Brittne Halford, Lindsay Schmidt, David Harro, Donald Giacherio and Osamu Tanabe.
