U-M researchers will use a $2.5 million grant from the Agency for Healthcare Research and Quality to study long-term health outcomes and cost-effectiveness of newborn screening.
This study, led by Lisa A. Prosser, could impact lawmakers’ recommendations on panels of tests given to newborns for potentially harmful disorders.
The five-year, multi-disciplinary study will use computer modeling to simulate clinical trials of newborn screening programs. The study aims to provide comparative effectiveness evidence and cost-effectiveness results for newborn screening for three rare, but potentially disabling or fatal, conditions:
• Krabbe disease, a degenerative disorder that affects the nervous system.
• Pompe disease, an inherited disorder that disables the heart and skeletal muscles.
• Phenylketonuria (PKU), an inherited disorder that can cause intellectual and developmental disabilities if not treated.
“New technology has made it easier and less expensive to screen newborns for additional disorders,” says Prosser, the principal investigator on the project, associate professor of pediatrics and a core faculty member of the CHEAR Unit.
“However, there are costs and potential harms associated with screening follow-up and treatment. It’s important to recognize both the benefits and costs of newborn screening programs. Decisions about new conditions for mandatory screening should also reflect public opinion for public health priorities,” says Prosser, who also is an associate professor of health management and policy at the School of Public Health.
The study also will conduct a survey of public values for newborn screening programs. This information will be of direct interest to state and national policy makers when considering new conditions for recommended newborn screening panels.
Prosser’s research often focuses on comparative and cost-effectiveness of children’s health interventions. She is a member of the external evidence review group for the Advisory Committee on Heritable Disorders in Newborns and Children. She also holds adjunct faculty appointments at Harvard Medical School and the Harvard School of Public Health.
Co-investigators on this project include Dr. Beth Tarini and Wen Ye of U-M, Dr. Alex Kemper of Duke University, Dr. James Perrin of Massachusetts General Hospital and Janice Bach of the Michigan Department of Community Health.
